これも意味不 今のワクチンなんてどれもオリジナル武漢株であるD614のSタンパクもとに作ってるぞ 問題はこのD614に対して以下の操作がしっかりしされてるか most vaccine developers, including Moderna and Pfizer-BioNTech, took a lesson from studies of SARS-CoV-1 and Middle East respiratory syndrome (MERS) coronavirus to slow S-protein shedding by introducing non-native prolines into S2 (14). Those who developed the Johnson and Johnson and Novavax vaccines had the prescience to also remove the furin site. By contrast, the developers of the University of Oxford?AstraZeneca vaccine opted for the wild-type S protein (containing D614), as is also the case for the inactivated virus vaccine produced by Sinovac. To be clear, other variables, especially antigen-delivery systems, likely account for efficacy differences among these vaccines. However, apples-to-apples studies in animals make clear that both engineered prolines and furin-site ablation contribute to vaccine effectiveness
>>312 死んでないぞ? アカゲザルの実験でしっかり下気道および上気道での感染ふせいでる Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates https://www.nejm.org/doi/full/10.1056/NEJMoa2024671
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